The construction of a building inevitably changes the surrounding microclimate. Many city officials require extensive wind studies before issuing a building permit, which can be obtained through Computational Fluid Dynamics (CFD) simulations. Investigating wind conditions for 12 wind directions has previously been considered sufficient in most literature and industry. However, the effect of varying the number of simulated wind directions is still not fully understood. A better understanding of the impact of the number of simulated wind directions may enable more efficient pedestrian wind comfort studies that identify relevant uncertainties.